FITC -derivatives

The labelling of dextran with fluorescein via its FITC derivative was first described in a publication in 1973 by de Belder and Granath (ref.1). Now it is a long-established method for obtaining fluorescent-labelled polysaccharides. These products are designated as FITC-derivatives. The fluorescein moiety is bound by a thiocarbamoyl-linkage which displays good stability in-vitro and in-vivo.